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Image Search Results
Journal: Nature genetics
Article Title: Therapeutic modulation of eIF2α-phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
doi: 10.1038/ng.2853
Figure Lengend Snippet: a–d, Immunostaining for PABPC1 in the cervical spinal cord of control and ALS patients. a) PABPC1 is expressed in spinal cord motor neurons, and is localized throughout the cytoplasm in a diffuse pattern. b ) Occasionally PABPC1 cytoplasmic accumulations were observed in normal motorneurons (arrow). c) In ALS patient motor neurons, PABPC1 is present in distinct cytoplasmic and dense accumulations (arrow). d ) PABPC1 cytoplasmic accumulations were also observed in the ALS motorneurons where there was a clearing in the middle. Scale bars, 30 μm. e ) The number of motor neurons containing cytoplasmic accumulation of PABPC1 in ALS patients was significantly greater ( p =0.01, one-tailed Mann-Whitney test) than in motor neurons from controls. For quantification of accumulations of PABPC1 in individual normal versus ALS cases, see . n=5 controls, 4 ALS patients, mean ± s.e.m.
Article Snippet: The tissue was cut into 7 μm sections and
Techniques: Immunostaining, One-tailed Test, MANN-WHITNEY